Electroconvulsive seizures mitigate psychotic-like phenotype in mice lacking adenosine A2A receptor
Paula Álvarez-Montoya, Marta Valle-León, Jordi Bonaventura, Sergi Ferré, Marc López-Cano, Francisco Ciruela · FENS Forum 2024
Schizophrenia presents as a complex psychiatric disorder characterized by a heterogeneous genetic and neurobiological background. Unfortunately, the prevailing mechanistic remains incompletely elucidated. A dopaminergic basis for schizophrenia has been proposed, implicating an upregulation in dopaminergic neurotransmission. This notion is supported by observations of behavioral hypersensitivity to dopamine receptor-activating drugs in individuals with schizophrenia, as well as postmortem analyses revealing elevated density of dopamine D2 receptors (D2R) in the striatum of schizophrenia patient
ePoster · Neuroscience