Individual behavioral profiling as a translational approach for assessing treatment responsiveness in an animal model of PTSD
Maja Snippe Strauss, Ishita Sarkar, Amir Benhos, Adi Tenenhaus Zamir, Gal Richter-Levin · FENS Forum 2024
The first-line pharmacological treatments for PTSD patients are serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs). However, both treatments achieve full recovery in fewer than 30% of patients, underscoring the variability in responsiveness among individuals. To this day, there is a profound lack of knowledge regarding the neural mechanisms underlying responsiveness to these treatments. In our study, employing a male rat model of PTSD, we utilized individual behavioral profiling (IBP) following comprehensive behavioral assessments to distinguish between trauma-affected
ePoster · Neuroscience