Shedding light on central nervous system trehalose activity
Davide Camazzola, Simone Serrao, Alessandro Esposito, Giuseppe Martano, Giuseppe Paglia, Fabrizia Claudia Guarnieri, Luca Murru · FENS Forum 2024
Trehalose is a natural disaccharide formed by a 1,1-glycosidic bond between two α-glucose units, widely used in food industry due to its peculiar chemical properties. In the last 20 years the involuntary trehalose intake is exponentially increased, with unknown long-term effects on the population. Furthermore, circulating trehalose is able to reach the CNS. Importantly, trehalose induces autophagy in an mTORC1-independent manner activating the transcription factor EB (TFEB), the master transcriptional regulator of autophagy-lysosomal biogenesis. Accordingly, several studies indicated that treh
ePoster · Neuroscience