Insights into the pharmacological effects of a novel compound on glycine receptor function
César O. Lara Sanhueza, Ana María Marileo, Victoria San Martín, Omayra Contreras, Luis G. Aguayo, Patricio Castro, Jorge Fuentealba, Gustavo Moraga-Cid, Carlos F. Burgos, Gonzalo E. Yévenes · FENS Forum 2024
Ionotropic glycine receptors (GlyRs) are chloride-permeable ligand-gated ion channels expressed in neurons of the central nervous system. These receptors play a key role in regulating neuronal membrane potential, impacting various physiological processes, including motor control, respiratory rhythm, and pain modulation. Consistent with its relevance, positive allosteric modulators (PAMs) of GlyRs have shown analgesic effects in chronic pain models. A promising group of glycinergic PAMs are the tricyclic sulfonamides (TS), such as AM-1488, which has been majorly studied using biochemical and hi
ePoster · Neuroscience