A novel core planar cell polarity (PCP) signaling protein player in axonal initial segment formation and function
Jerome Ezan, Ana Dorrego-Rivas, Sonia Poirault-Chassac, Arne Battefeld, Nathalie Aubailly, Charlotte Isch, Nathalie Sans, Mireille Montcouquiol · FENS Forum 2024
The axonal initial segment (AIS) is a crucial neuronal subdomain that coordinates the axo-dendritic polarity establishment and maintenance and constitutes the site for action potential (AP) initiation. Its integrity relies on proteins like AnkyrinG (AnkG) which, by organizing the cytoskeleton, anchor the ionic channels necessary for AP generation. Many AIS proteins are linked to neurodevelopmental disorders (NDD) like epilepsy or autism and the AIS proteome deciphering is warranted to provide insight into novel therapeutic targets for the treatment of human diseases of the nervous system.Plana