N,N-Dimethyltryptamine has a protective effect against oxygen-glucose deprivation in a rat primary culture model of the blood-brain barrier
Judit Vigh, Marcell László, Anna Kocsis, Zsófia Hoyk, Fruzsina R. Walter, Attila Szabó, Zoltán Nagy, Mária A. Deli, Sándor Nardai · FENS Forum 2024
Disruption of the blood-brain barrier (BBB) is a key factor in the development of stroke. N,N-dimethyltryptamine (DMT) is a hallucinogen alkaloid widely found in plants and animals. Beneficial effects of DMT was described in a rat stroke model, but BBB functions were not studied. Our aim was to examine the effect of DMT on the functions of the BBB following oxygen-glucose deprivation and reoxygenation (OGDR) in a rat primary BBB co-culture system.To model stroke in vitro, OGD was introduced for 6 hours on the BBB model, followed by reoxygenation for 24 hours with or without the addition of DMT
ePoster · Neuroscience