Rescuing efficacy of cognitive and multimodal stimulation on neuroinflammation in two mouse models of Parkinson’s disease
Giulia Ponterio, Martina Montanari, Ilham El Atiallah, Francesca Balsamo, Eugenia Landolfo, Robert A. Rissman, Francesca Gelfo, Paola Bonsi · FENS Forum 2024
Parkinson's disease (PD) is a neurodegenerative disorder characterized by resting tremor, rigidity, bradykinesia and a plethora of non-motor manifestations. In particular, the onset of motor symptoms is often preceded by mild cognitive impairment, which can progress to overt dementia. Neuroinflammation has recently emerged as one of the key processes involved in the pathogenesis of PD. Indeed, markers of inflammation were found in the brains of PD mouse models.In the present work, we evaluated the expression of inflammatory markers at 2 and 6 months of age in the striatum and hippocampus of tw
ePoster · Neuroscience