Astrocytes act as detectors of sensory input and calcium-dependent regulators of experience-dependent plasticity in cortical networks
Rheinallt Parri, Neville Ngum, Amjad Bazzari, Francis Delicata, Adele Ludlam, Eric Hill, Richard Elsworthy, Stanislaw Glazewski · FENS Forum 2024
In rodents, whisker deprivation induces changes in neuronal responses in the somatosensory barrel cortex called Experience dependent plasticity (EDP). There are two general forms of synaptic EDP: Hebbian, and Homeostatic. Our aim was to determine the role of astrocytes in these processes, using in vivo whisker deprivation and ex vivo fEPSP recordings. In response to a week of unilateral all-whisker sensory deprivation of one side of the snout, a PKA-dependent form of long term potentiation (LTP) emerges at L4-L2/3 synapses in the contralateral barrel cortex, in addition to the NMDA receptor de
ePoster · Neuroscience