Topic: TRPV2 clustering

We previously reported that TRPV2 can be activated by mechanical stimulation which enhances axonal outgrowth in developing neurons (Shibasaki et al., J. Neurosci. 2010). However, the molecular mechanisms governing the contribution of TRPV2 activation to axonal outgrowth remain unclear. In this study, we examined this mechanism. Overexpression of TRPV2 enhanced axonal outgrowth in a mechanical stimulus-dependent manner. Accumulation of TRPV2 at the cell surface was 4-fold greater in the growth cone compared to the soma. In the growth cone, TRPV2 is not static, but dynamically accumulates (withi