Deficit of parvalbumin-positive interneurons and overfunction of somatostatin-positive interneurons are involved in the hippocampus-dependent cognitive impairment of the Ts65Dn mouse model of Down syndrome
Giulia Colombo, Alberto Potenzieri, Ilaria Colombi, Andrea Contestabile, Laura Cancedda · FENS Forum 2024
Dysfunction of GABAergic interneurons during sensitive time windows plays a crucial role in the etiopathogenesis of neurodevelopmental disorders. GABAergic transmission through Cl-permeable GABAA receptors (GABAAR) is depolarizing in pyramidal neurons of the CA1 region of the hippocampus of the Ts65Dn mouse model of Down syndrome. This depends on the upregulation of the Cl-importer NKCC1 and leads to an impairment of synaptic plasticity and memory in Ts65Dn adult mice. Accordingly, inhibiting NKCC1 rescues the Ts65Dn phenotype. However, the contribution of specific interneuron subpopulations t
ePoster · Neuroscience