Changes in striatal spiny projection neurons’ properties and circuitry in a mouse model of autism spectrum disorder with cholinergic interneuron dysfunction
Juliette Graniou, Xavier Caubit, Pascal Salin, Lydia Kerkerian-Le Goff, Laurent Fasano, Paolo Gubellini · FENS Forum 2024
Striatal cholinergic interneurons (SCINs) are implicated in several pathologies involving the basal ganglia, including motor and neuropsychiatric disorders. They are key modulators of striatal circuit function at both pre- and postsynaptic level, regulating corticostriatal synaptic transmission/plasticity and striatal neuron excitability. We have recently characterized a mouse model of autism spectrum disorder (ASD) obtained by the targeted deletion of the ASD-linked Tshz3 gene in cholinergic neurons (Chat-cKO): these mice show repetitive and restricted behaviors (RRBs) paralleled by a signifi
ePoster · Neuroscience