Study of the role of nitric oxide in glioblastoma cellular populations
Julia Lara Gutierrez Arroyo, Elvira María Corbonell Martinez, Conrodo Martínez Cadenas, Pia Gallego Porcar, Luis German González Bonet, María de los Ángeles Marques Torrejón · FENS Forum 2024
Glioblastoma, a highly aggressive brain tumor, poses a formidable challenge due to factors such as angiogenesis, diverse mutations, and evasion of apoptosis. Nitric oxide (NO) plays multifaceted roles in physiological processes, including vasodilation, blood pressure regulation, neurotransmission, and immune response. In the context of glioblastoma, understanding the interaction between NO and tumor cells is crucial. Our study utilizes human and mouse glioblastoma stem cells to investigate how NO influences cell proliferation.We modulate NO activity by either enhancing (using SNAP) or inhibiti
ePoster · Neuroscience