Topic: tuning space

Animals encode sensory stimuli with precisely timed activity across modalities. For example, mice can rapidly recognize odors, independent of their concentration, based on complex spatiotemporal patterns of mitral and tufted cell (MTC) activity in the olfactory bulb. Yet, it remains unknown how sequential MTC activity is organized, and what role sequential activity plays in guiding perception. Here, we performed fast 2-photon calcium imaging of hundreds of MTCs with sub-sniff temporal resolution to a battery of odors. We constructed a space of MTC tuning using the pairwise correlations between