Microglia rescue neurons from aggregate-induced neuronal dysfunction and death through tunneling nanotubes
Hannah Scheiblich, Frederik Eikens, Lena Wischhof, Sabine Opitz, Kay Jüngling, Csaba Cserép, Susanne V. Schmidt, Tracy Bellande, Balázs Pósfai, Charlotte Geck, Jasper Spitzer, Alexandru Odainic, Stephanie Schwartz, Ibrahim Boussaad, Reiko Krüger, Enrico Glaab, Donato DiMonte, Daniele Bano, Ádám Dénes, Eike Latz, Ronald Melki, Hans-Christian Pape, Michael T. Heneka · FENS Forum 2024
Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder characterized by the formation of cellular inclusions inside neurons that predominantly consist of misfolded α- synuclein (α-syn), leading to neuronal dysfunction. The clearance of α-syn aggregates by microglia, the brain’s resident innate immune cells, has emerged as particularly critical for the progression of PD, given their demonstrated ability to scavenge extracellular α-syn with the highest capacity among all brain cells. Here, we present a novel mechanism of neuron-microglia communication through t
ePoster · Neuroscience