Combining transcranial ultrasonic stimulation of the human basal forebrain with simultaneous electroencephalography
Maximilian Lueckel, Dorina Laurila-Epe, Jennifer Weinberg, Saman Seifpour, Suhas Vijayakumar, Til Ole Bergmann · FENS Forum 2024
Transcranial ultrasonic stimulation (TUS) promises non-invasive and highly precise neuromodulation of small, deeply located brain regions like the basal forebrain (BF) – a cholinergic hub that is affected in neurodegenerative diseases like Alzheimer’s. Here, we aimed to combine TUS of the BF with simultaneous electroencephalography (TUS-EEG), expecting widespread desynchronization of cortical neuronal activity due to TUS-induced increases in cholinergic BF signalling.TUS transducer placement and targeting were individually planned and monitored using MRI scans as well as acoustic simulations a
ePoster · Neuroscience