Topic: Tween-80

As the use of cannabinol, often marketed as a sleep aid, is increasing, we aimed to investigate the effect of this substance on sleep. We evaluated the effect of a low dose (1 mg/kg) of cannabinol in rats using electrocorticography and electromyography. Three groups were compared: rats that received saline, vehicle (1% Tween-80 dissolved in saline), and cannabinol dissolved in vehicle. We recorded data for 24 hours after a single injection, and for 7 days with injections taking place every day. Cannabinol decreased the percentage of time spent in non-REM sleep at different times across the day