Topic: two-alternative forced-choice task

The perception of an ambiguous stimulus rely on the activation of multiple cortical areas, operating a sensorimotor transformation along the cortical hierarchy. Furthermore, choice related information is found as upstream as the primary sensory areas, suggesting bi-directional communication at all stages of the cortical hierarchy. How do sensory and choice related activities flow and organize across multiple brain areas? Here, we designed a two-alternative forced-choice task (2AFC) in which mice compared stimulation frequencies applied to two adjacent vibrissae. Using two-photon functional ima

In social species, signals from conspecifics can help interpret ambiguous sensory information crucial for survival, such as locating food sources or detecting predators. To investigate the influence of conspecific cues on goal-directed decision-making, we devised a two-alternative forced-choice task for pairs of freely moving mice positioned facing each other. Water-restricted mice were trained to discriminate between visual stimuli indicating the location of a water reward. To evaluate their reliance on conspecific cues under conditions of uncertainty, we positioned the reward on the same sid

Humans and social animals interpret the body language of others to infer intentions and adjust their actions instantaneously. To explore neural representations of conspecific kinematics during goal-directed behavior, we trained pairs of freely moving mice to jointly perform a two-alternative forced-choice task. The mice had to discriminate the location of a visual grating to earn water rewards. Using high-speed videography, we showed that mice engage in stereotypical trajectories from the trial initiation site to the chosen reward lick port across hundreds of trials. By decomposing movement in