ePoster · Neuroscience
Spatiotemporal dynamics and targeted functions of locus coeruleus norepinephrine in a learned behavior
Gabi Drummond,Vincent Breton-Provencher,Mriganka Sur · COSYNE 2022
Thu, Mar 17, 2022
The locus coeruleus (LC) serves as the primary source of the neuromodulator, norepinephrine (NE), in the brain. Through a widely divergent set of projections, LC neurons have been suggested to release NE ubiquitously to regulate arousal and attention. However, LC-NE is implicated in more precise roles such as mediating learning, promoting task execution, and signaling unexpected uncertainty. Whether and how LC-NE activity facilitates these distinct aspects of behavior is unknown. Here, we show that LC-NE activity displays distinct spatiotemporal dynamics to enable two functions during a learne