Aged microglia in Alzheimer’s disease display a senescent and pro-inflammatory profile associated with mitochondrial oxidative stress
Vicente Roca Agujetas, Jorge Moreno-Fernández, Cristina Núñez-Díaz, Carmen Romero-Molina, José Carlos Dávila, Sebastián Jiménez-Muñoz, Marina Mejías-Ortega, María Manfredi-Lozano, Elisabeth Sánchez-Mejías, Nicolás Capelo-Carrasco, Clara García-Mayor, Clara Muñoz-Castro, Alberto Pascual, Antonia Gutiérrez, Marisa Vizuete, Javier Vitorica · FENS Forum 2024
Microglial phenotype during Alzheimer’s Disease (AD) continuum is under debate. At early stages, a protective phenotype with the typical DAM profile would participate in plaque compaction and Aβ degradation. Instead, human AD microglia (HAM) show an enhance aged/degenerative profile, supporting a microglial dysfunction as a central mechanism in AD aetiology. Recent findings from our lab described that peri-plaque microglia are highly reliant on oxygen levels and mitochondrial integrity. Nevertheless, mitochondrial implication in aged microglia during the disease progression remains unclear. Th
ePoster · Neuroscience