Topic: type I interferon receptor

Type I interferons are most commonly associated with their essential role in the innate immune response. However, the actions of the type I interferon receptor are not limited to the scenario of infection. Previous work from our group revealed that type I interferon receptor signaling, specifically in a subtype of glia cells (astrocytes), critically modulates hippocampal synaptic plasticity and cognitive function in adult mice under physiological conditions. Since cytokines such as type I interferons are implicated in modulation of neurogenesis and brain development, in this work we started to