Prediabetes and type 2 diabetes affect tau phosphorylation patterns in murine models of Alzheimer’s disease
Maria Vargas Soria, Miriam Corraliza Gomez, Carmen Infante Garcia, Alan W. Stitt, Rafael Simó, Monica Garcia Alloza · FENS Forum 2024
Alzheimer’s disease (AD) is the most common cause of dementia. Metabolic disorders, including prediabetes (preDM) and type two diabetes (T2D) increase the risk to suffer AD, and may contribute to dysfunctional brain insulin signaling and abnormal tau phosphorylation. Thus, we measured cortical tau phosphorylation at Ser-199, Ser-202/Thr-205, Ser-396, Ser-404, Thr-217 and Thr-231 residues in animals reproducing PreDM and T2D, alone or with AD. We analyzed the relationship between tau phosphorylation and metabolic profile, Aβ levels, microglia activation, cytokines production and cognitive impai
ePoster · Neuroscience