Involvement of glioblastoma-derived extracellular vesicles in promoting endothelial cell remodelling: Implications for glioblastoma tumour progression
Swagatama Mukherjee, Prakash Pillai · FENS Forum 2024
Glioblastoma (GBM) tumors rely on neovascularization, driven by specific tumor signals that stimulate endothelial cell (EC) proliferation, migration, and differentiation. Moreover, extracellular vesicles (EVs) has emerged as a key mediator in tumor angiogenesis. This in vitro study assesses glioblastoma-derived EVs' (GD-EV) potential in endothelial cell remodelling (ECR). Glioblastoma cell (U87 MG) conditioned media, treated with the chemotherapeutic drug, Temozolomide (TMZ), EV inhibitor (GW4869), or TMZ+EV inhibitor, were incubated with endothelial cells, HUVEC. Dose-& time-dependent stu
ePoster · Neuroscience