A novel sEH inhibitor reduces inflammation and promotes neuroprotective effects by modulating gut microbiota
Júlia Jarne Ferrer, Christian Griñán-Ferré, Lluisa Miró, Anna Perez-Bosque, Santiago Vazquez, Mercè Pallàs · FENS Forum 2024
Alterations along the brain-gut axis participate in the pathogenesis of neurodegenerative diseases. Recent data suggest that the gut microbiota partially exerts its action by modulating neuroinflammation. Interestingly, neuroinflammation has been postulated as one of the leading causes of Alzheimer’s Disease (AD). Therefore, targeting brain inflammation has been suggested as a promising therapeutic strategy to cope with AD. In this regard, neuroinflammation has been related to the soluble epoxide hydrolase (sEH) enzyme, which is upregulated in the brains of AD patients and mice models of AD. C
ePoster · Neuroscience