A novel ubiquitin ligase adaptor PTPRN suppresses seizure susceptibility through endocytosis of NaV1.2 sodium channels
Zhuo Huang, Yifan Wang, Hui Yang, Na Li, Lili Wang, Shiqi Liu, Huifang Song, Xinyue Ma, Chao Peng, Jiexin Chen, Chang Guo, Jie Dong · FENS Forum 2024
Intrinsic plasticity, a fundamental process enabling neurons to modify their intrinsic properties, plays a crucial role in shaping neuronal input-output function and is implicated in various neurological and psychiatric disorders. Despite its importance, the underlying molecular mechanisms of intrinsic plasticity remain poorly understood. Here, we identified a new ubiquitin ligase adaptor, protein tyrosine phosphatase receptor type N (PTPRN), as a regulator of intrinsic neuronal excitability in the context of temporal lobe epilepsy. We discovered that PTPRN facilitates NaV1.2 sodium channel en
ePoster · Neuroscience