Utilizing network-based algorithms for drug repurposing through a meta-analysis of East Asian genome-wide association studies in depression
Ping Lin Tsai, Hui Hua Chang · FENS Forum 2024
Translating insights from genome-wide association studies (GWASs) into practical therapies for depression poses a significant challenge. Our objective is to address this challenge by utilizing network-based algorithms on GWAS outcomes for drug repurposing. This approach aims to advance precision medicine, specifically focusing on East Asian populations.Our research involved an initial meta-analysis of GWASs to reveal genetic variants linked to depression, utilizing data from large-scale studies including the Taiwan Biobank (Ntotal: 19389) and BioBank Japan (Ntotal: 178630). We employed a rando
ePoster · Neuroscience