Timing and transmission: the role of axonal action potential propagation speed in the synchronization of foveal vision
Annalisa Bucci, Marc Büttner, Niklas Domdei, Federica Rosselli, Matej Znidaric, Roland Diggelmann, Martina De Gennaro, Cameron Cowan, Wolf Harmening, Andreas Hierlemann, Botond Roska, Felix Franke · Bernstein Conference 2024
Precise timing of action potentials is crucial for processing sensory information. Axonal length and propagation speed largely determine the time necessary for action potentials to reach postsynaptic neurons. Within the retina, retinal ganglion cell (RGC) axons form the retinal nerve fiber layer (RNFL), a highly organized layer with species-specific axonal arrangements. The human RNFL is characterized by unmyelinated axons, resulting in slow signal transmission, and by the presence of the fovea, a specialized region enabling high-resolution vision located temporally to the optic nerve head (i.