Topic: unbiased stereology

Spinocerebellar ataxia type 1 (SCA1) is an autosomal dominant neurodegenerative disease manifested by cerebellar disorders. Alongside cerebellar symptoms, individuals with SCA1 often exhibit a range of ophthalmic abnormalities, particularly those affecting the optic nerve and retina. However, the mechanisms underlying visual disturbances in SCA1 remain unclear.Therefore, in this study, we aimed to analyze the retinal cell layers of mice with SCA1.Sixteen eye samples were obtained from 6-month-old mice (8 from SCA1 mice and 8 from wild-type). The volume of the retina, as well as the volume and