Persistent decision-making in mice, monkeys, and humans
Veldon-James Laurie, Akram Shourkeshti, Cathy S Chen, Alexander B Herman, Nicola M Grissom, Becket Ebitz · COSYNE 2025
Humans have the capacity to persist in behavioural policies, even in challenging environments that lack immediate reward. Our persistence could be the scaffold on which many higher executive functions are built. However, it remains unclear whether humans are uniquely persistent or, instead, if this capacity is widely conserved across species. This question is all the more important because we regularly use animals, like mice or monkeys, as models for humans experiencing neurobiological conditions in which persistence is compromised. Here, we compared humans with mice and monkeys in harmonised