Unpredictable Rewards, Predictable Maps: Reward uncertainty induces hippocampal place cell remapping in parallel reference-frames
Tessereau Charline, Feng Xuan, Jack R Mellor, Peter Dayan, Daniel Dombeck · COSYNE 2025
In volatile environments, humans and animals face different forms of uncertainty to which they must adapt to thrive. However, our understanding of the neural basis of this adaptation is incomplete, despite, for instance, long-standing arguments about its possible dependence on neuromodulation. Here, we take advantage of the well-known spatial remapping of hippocampal place cells in the face of environmental change to interrogate these processes. We performed calcium imaging in CA1 place cells using a new Uncertain Reward virtual reality Task (URTask), in which mice run along a linear track and
ePoster · Neuroscience