Butyrylcholinesterase as a potential biomarker for depression: Insights from a translational study
Berkan Bozkurt, İzel Cemre Aksahin, Toghrul Almammadov, Deniz Ceylan, Safacan Kolemen, Hale Yapici Eser · FENS Forum 2024
Depression, a prevalent psychiatric disorder that significantly impacts quality of life. Cholinergic transmission dysregulation potentially contributes to emotional and behavioral disturbances. While acetylcholinesterase is commonly studied in depression, the role of butyrylcholinesterase (BChE) remains unclear. We recently developed the butyrylcholinesterase (BChE)-activatable molecular sensor (BCC) for real-time visualization of BChE activity, demonstrating its efficiency in vitro and in tumor-bearing mice. In this translational study, we employed BCC to investigate BChE changes in depressio
ePoster · Neuroscience