Rabphilin 3A: From NMDA receptor synaptic retention to neurodevelopmental disorders
Marta Barzasi, Lisa Pavinato, Chiara Galizia, Monica Di Luca, Alfredo Brusco, Fabrizio Gardoni · FENS Forum 2024
Rabphilin 3A (Rph3A) is a synaptic protein crucial for regulating exo- and endocytosis processes at presynaptic terminals and dendritic spines. The protein promotes the stabilization of the NMDA-type glutamate receptors (NMDARs) at the cell surface, forming a ternary complex with the PSD-95 and GluN2A subunit of the receptor. This complex is needed for long-term potentiation induction and NMDAR-dependent hippocampal behaviors, such as spatial learning. Rph3A overexpression increases dendritic spine density and GluN2A-containing NMDARs at synaptic membranes. Overall, these results suggest that
ePoster · Neuroscience