The hippocampal lipid alterations in an Alzheimer's disease model
Elif Keskinoz, Musa Celik, Ezgi Sila Toklucu, Kerem Birisik, Mesut Bilgin, Devrim Oz Arslan · FENS Forum 2024
Our aim is to investigate the effect of choline, fish oil, and uridine-5'-monophosphate (UMP) supplementation on lipid profiles in the 5XFAD mouse model of Alzheimer's disease (AD) was to characterize cholesterol, glycerophospholipids (GPLs), sphingolipids (SLs), glycolipids (GLs), lysophospholipids (lyso GPLs) and lysophospholipid acyltransferases (lyso GPL O-ATs), and glycerophospholipid (GPL Os).Lipidomic analysis was performed on hippocampal brain tissue samples from 3-, 6- and 9-month-old 5XFAD mice and littermate controls using cutting-edge mass spectrometers with direct infusion (shotgu
ePoster · Neuroscience