VRK2 deficiency elicits aggressive behavior in female zebrafish
Ryohei Umeda, Nobuyuki Shimizu, Hitoshi Teranishi, Kenshiro Shikano, Hirotaro Urushibata, Hiroshi Shiraishi, Takatoshi Hikida, Toshikatsu Hanada, Reiko Hanada · FENS Forum 2024
Vaccinia-related kinase 2 (VRK2) VRK2 is one of the serine/threonine kinases that was originally identified in highly proliferative cells such as thymocytes and fetal liver cells. GWAS studies were reported that VRK2 was related molecule with neuropsychiatric diseases. And in vitro studies reported that VRK2 plays an important role in cell division and cell cycle regulation. However, little is known about the molecular mechanism and physiological function of VRK2 on the central nervous systems in vivo. In this study, we established vrk2 deficient (VRK2 KO) zebrafish and found that VRK2 KO body
ePoster · Neuroscience