Ethanol extract of Vanilla planifolia stem reduced PAK6 expression and induced cell death in glioblastoma cells
Hui Hua Chang, Bing-Chen Tsai, Yi-Xuan Lin, Yuan-Shuo Hsueh · FENS Forum 2024
Glioblastoma multiforme (GBM) is a highly malignant brain tumor with poor prognosis after conventional treatment. Therefore, potential treatment strategies and novel therapeutic targets have gained increased attention. Vanilla planifolia is a source of vanilla flavoring due to its high vanillin content, and several studies have shown its antitumor activity. Our data revealed that an ethanol extract of vanilla planifolia stem (VAS) at 200 ng/μl significantly reduced cell viability and colony formation in GBM cells. VAS also induced autophagy, as shown by MAP1LC3 cleavage. Further RNA-seq analys
ePoster · Neuroscience