Advancing in-vivo brain vasculature imaging: Super-resolution 3D ultrasound localization microscopy of the mouse brain and in non-human primate using RCA probes
Adrien Bertolo, Jeremy Ferrier, Tanguy Delaporte, Julien Claron, Oscar Demeulenaere, Mickael Tanter, Pierre Pouget, Bruno Osmanski, Mathieu Pernot, Thomas Deffieux · FENS Forum 2024
3D ultrasound localization microscopy (3D-ULM) allows in vivo quantification of blood vessel velocities in the mouse brain using matrix arrays, but it requires complex electronics, and the field of view remains limited [1]. Here, we investigate how low channel count Row-Column Addressing (RCA) probes allow 3D-ULM to be performed in the whole mouse brain non-invasively and in the visual cortex of a non-human primate after craniotomy.An IcoPrime 4D-RCA probe (80+80 elements, 15 MHz, pitch 0.11 mm, Iconeus) was driven by an Iconeus One scanner. For the mouse experiment, the probe was mounted on a
ePoster · Neuroscience