Modulatory role of the neuropeptide VIP in the central amygdala on stress and anxiety function in mice
Federico Ferro, Quirin Krabichler, Valery Grinevich, Jens Hannibal, Nicolas Singewald, Karl Ebner · FENS Forum 2024
Vasoactive-intestinal-polypeptide (VIP) is a neuropeptide that is localized together with its receptors (VPAC1 and VPAC2) in brain areas of the stress and anxiety circuit, such as central amygdala (CeA). However, the exact role of the CeA-VIP system in stress and anxiety function is not fully known. By using a pharmacological and chemogenetic approach we investigated the role of VIP in the CeA on anxiety and stress responses of mice. First, we administered specific VIP/VPAC receptor agonists/antagonists bilaterally into the CeA to evaluate effects on anxiety- and stress-related behaviors as we
ePoster · Neuroscience