Neuroprotective strategies with neurotrophic factors against selective neuronal loss
David Diaz, Laura Pérez-Revuelta, David Pérez-Boyero, Daniel Gustavo Neira Mora, Carmelo Ávila-Zarza, Jesús G Briñón, Eduardo Weruaga · FENS Forum 2024
PCD mice suffer the postnatal death of cerebellar Purkinje neurons and mitral cells of the olfactory bulb (OB). They are also defective in IGF1, but little is known about other neurotrophic factors, which may act as neuroprotective molecules.The expression of different neurotrophic factors (IGF1, BDNF, VEGF-A and VEGF-B) was analyzed by qPCR and ELISA around cerebellar and bulbar degenerations of PCD mice. Then, we applied two different therapies depending on the affected region.1. We refined healthy bone marrow transplants to reduce the degeneration of mitral cells. PCD mice were transplanted
ePoster · Neuroscience