Unveiling a novel neuropeptide interplay: Opposing actions of oxytocin and relaxin-3 on ventral hippocampal dentate gyrus neuronal activity – Rat and human studies
Aleksandra Trenk, Kinga Przybylska, Anna Gugula, Aleksandra Nogaj, Agus Hartoyo, Camila de Ávila, Mohammed Akhter Hossain, Anthony J. Intorcia, Geidy E. Serrano, Thomas G. Beach, Alessandro Crimi, Diego F. Mastroeni, Andrew L. Gundlach, Anna Blasiak · FENS Forum 2024
The oxytocin (OXT) and relaxin-3 (RLN3) signalling systems are involved in shaping social and stress-related behaviours, but the interplay of these neural networks in relevant brain regions including the ventral hippocampus dentate gyrus (vDG), is under explored. The rat vDG is strongly innervated by OXT and RLN3-containing nerve fibres, but possible interactions of these neuropeptide systems in vDG are unknown. Therefore, we investigated the influence of OXT and RLN3 signalling, separately and in combination, on rat and human vDG neurons. Multiplex in situ hybridization (ISH) identified a mod
ePoster · Neuroscience