A midbrain-extended amygdala pathway controls contextual fear memory
Kinga Müller, Biborka Bruzsik, Laura Rovira-Esteban, Enrica Paradiso, Orsolya Papp, Zsuzsanna Fekete, Zsofia Reeb, Mate Toth, Cecilia Szekeres-Paraczky, Peter Szocsics, Jose Miguel Blasco-Ibanez, Orsolya Mihaly, Zsofia Magloczki, Francesco Ferraguti, Eva Mikics, Norbert Hajos · FENS Forum 2024
Neuronal circuits located in the midbrain play a critical role in controlling defensive behavior. However, it is still elusive how different neuron types contribute to distinct behavioral outcomes during the presence of threat. In this study, we investigated neurons expressing vasoactive intestinal polypeptide (VIP) in the ventral periaqueductal gray (PAG) and dorsal raphe nucleus in mice. These VIP-expressing neurons also expressed tyrosine hydroxylase (TH), a marker for dopaminergic cells. Using viral tracing conducted in Vip-Cre mice, we observed that these VIP-expressing neurons innervated
ePoster · Neuroscience