Layer-specific microcircuit synaptic ultrastructure comparison of sensory first and higher order thalamocortical projections into somatosensory cortices
Pablo J. Martin-Correa, Javier Rodriguez-Moreno, Mario Rubio-Teves, Brigitte Marshallsay, Astrid Rollenhagen, Joachim Lübke, Francisco Clascá · FENS Forum 2024
Thalamocortical synapses are key cellular links in sensory, motor and cognitive information processing. In rodents, ventral posteromedial thalamic nucleus (VPM) axons innervate both layer 4 of primary and secondary somatosensory cortex (S1, S2). Posterior thalamic nucleus (Po) projects to the same somatosensory areas as a “higher order” nucleus following a different layer pattern. Despite “primary” and “secondary” functional characterization, it is unknown if differences exist in VPM and Po axon synapse structure and their postsynaptic targets in secondary cortices. Here, we set out to 3D meas
ePoster · Neuroscience