Childhood trauma in the adult brain: The relationship between adverse childhood experiences, brain structure, and mental health in late adulthood
Anne Klimesch, Leonie Ascone, Götz Thomalla, Bastian Cheng, Ingo Schäfer, Jürgen Gallinat, Simone Kühn · FENS Forum 2024
Aim Adverse childhood experiences (ACEs) are related to worse mental health outcomes and reduced grey matter volume (GMV) in dorsolateral prefrontal cortex (DLPFC), amygdala (AMY), and hippocampus (HC), which has mostly been observed in samples of 12–50-year-old individuals. We hypothesize that these anomalies persist in middle- to old-age and brain structure (ROIs: HC, AMY, DLPFC) mediates the association of ACE with anxiety and depression symptoms. Methods The study uses data from the Hamburg City Health Study, which randomly sampled adults between 45–74 years (N=2,525) and tested them for a
ePoster · Neuroscience