Topic: ventral tegmental area (VTA)

The role of midbrain dopamine neurons in signalling reward prediction is well established, but it is becoming increasingly evident that these signals are heterogeneous. This raises the possibility that dopamine signalling during reward-seeking may vary in different striatal regions. We therefore examined dopamine signalling in the nucleus accumbens (NAc), dorsolateral striatum (DLS) or dorsomedial striatum (DMS) during choice and reward. We developed a mouse decision-making task and measured dopamine signals using fiber photometry. We expressed the GCaMP6f calcium sensor in the ventral tegment