Chemogenetic activation of thalamic subnuclei distinctively impairs sleep physiology
Philipp Janz, Joana Duarte, Jan Schulz, Simon Gross, Marie Bainier, Roger Redondo · FENS Forum 2024
Sleep deficits and altered sleep features, such as reduced NREM sleep, slow oscillations and sleep spindles are key hallmarks of many neurological disorders. Imaging studies indicate that dysregulation of thalamocortical circuits is associated with sleep abnormalities, but the underlying mechanisms remain poorly understood. Therefore, we studied the impact of thalamic hyperactivity on sleep physiology in rats using chemogenetics.Rats were injected with AAVs to express hM3Dq in either the mediodorsal (MDT), ventroposterior (VPT) or ventromedial thalamus (VMT). Electrodes were implanted in front
ePoster · Neuroscience