Single-cell uniparental disomies and mother-offspring interaction: A comparative study
Gianluca Como, Gianluca Serani, Federico Tozzi, Robert Wolff, Alice Melloni, Alessia Polito, Chiara Magliaro, Roberto Amici, Valter Tucci · FENS Forum 2024
Imprinted genes are expressed throughout the brain, exhibiting distinct allelic distribution in specific regions. To understand the imprinting status and their role in brain functions, we investigated the specific effects of uniparental disomy (UPD) by using a mouse model called Mosaic Analysis with Double Markers (MADM), which allows for the production of maternal and paternal UPD cell populations within the brain.By in silico enrichment analysis, chromosomes 2, 7, and 12 appear to be enriched in imprinted and behaviorally relevant genes, with different effects on post-natal development. Spec
ePoster · Neuroscience