Topic: vesicle dynamics

Synaptic strength is dynamically modulated depending on prior activity called short-term synaptic plasticity (STP). STP is displayed as either or both by facilitation or depression. Facilitation of recurrent excitatory synapses within neocortical networks is proposed to have a critical role in working memory. However, facilitation in the prefrontal cortex (PFC), a key cortical area for working memory, remains unclear. We aimed to investigate the synaptic properties, including STP, at synapses of the rat PFC layer 2/3 network and made a vesicle dynamics model to describe these properties. We fo