Topic: vesicular GABA uptake

Midbrain dopamine (DA) neurons are comprised of diverse neuronal subpopulations. For instance, there are subsets of DA neurons that express the vesicular glutamate transporter VGLUT2 and these cells can co-release the excitatory neurotransmitter glutamate. There are also several lines of evidence indicating that the inhibitory neurotransmitter gamma-amino-butyric acid (GABA) can be released from subsets of DA neurons. However, DA neurons do neither express the machinery to synthesize GABA nor the vesicular GABA transporter VGAT typically thought to be necessary for vesicular GABA uptake. Inste