Exploring dynamic interaction of oxytocin and relaxin-3 in modulating ventral CA3 neuronal activity in rats – insights from molecular and neurophysiological studies
Aleksandra Nogaj, Aleksandra Trenk, Kinga Przybylska, Andrew L. Gundlach, Anna Blasiak · FENS Forum 2024
The hypothalamic, peptide hormone, oxytocin (OXT), is a powerful modulator of social-, stress- and anxiety-related behaviors, as is the brainstem, neuropeptide relaxin-3 (RLN3). Recent studies indicate the involvement of KCNQ potassium channels in neuronal OXT and RLN3 signaling, with these neuropeptides displaying opposing excitatory and inhibitory actions, respectively. OXT receptors (OXTR) and RLN3 receptors (RXFP3) are expressed by neurons in the rat ventral hippocampal CA3 area (vCA3), which is involved in social behavior and anxiety control; but the possible interaction between OXT and R
ePoster · Neuroscience