Topic: VGF

Neuronal networks require precise coordination of excitatory and inhibitory synaptic connectivity to function properly. Regulation of parvalbumin-positive (PV+) interneuron activity is especially important for network function, and changes in PV+ interneuron activity correlate with an animal’s performance in learning tasks. Previously, changes in PV+ interneuron connectivity have been shown to regulate excitatory pyramidal cell activity. However, the mechanism via which PV+ interneurons control their own activity remains unknown. Here we used a chemogenetic approach to change the activity of P