Topic: VH disinhibition

Reversal learning, a form of cognitive flexibility disrupted in many brain disorders, involves switching from one response to another when the reward contingencies of the responses are reversed. The hippocampus, especially the ventral hippocampus (VH), connects to fronto-striatal circuits regulating reversal learning. Previous studies reported that hippocampal lesions impaired, whereas chemogenetic activation of VH facilitated, reversal learning acquisition in animal models. However, there is limited evidence on how VH activity affects distinct stages of reversal learning. Therefore, we examin