The impact of epileptic neuronal activity on oligodendrocyte lineage cells and myelination in a mouse model of focal cortical dysplasia
Adam Bogdanovič, Bohdana Hrušková, Nikola Vršková, Diana Pfeiferová, Monika Řehořová, Jan Kudláček, Přemysl Jiruška, Helena Pivoňková · FENS Forum 2024
Focal cortical dysplasia (FCD) is a regional malformation of cortical development frequently associated with pharmacoresistant epilepsy. It is caused by somatic mutations affecting the mTOR signaling pathway within excitatory neurons. At the cellular level, FCD manifests as the emergence of dysmorphic neurons, disrupted neuronal migration, and consequent alterations in neuronal circuitry, accompanied by seizure occurrence. It has been demonstrated that physiological neuronal activity stimulates oligodendrocyte lineage cells (OLCs) to proliferate, differentiate, and myelinate. We hypothesize th
ePoster · Neuroscience